川芎吸收入脑成分的UPLC—Q—TOF—MS分析(3)
[9] WangY H， Liang S， Xu D S， et al. Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong[J]. J Pharm Pharmcol， 2011， 63(2)： 261.
Analysis of chemical constituents of Chuanxiong Rhizoma absorbed into rat brain tissues by UPLC-Q-TOF-MS
ZUO Ai-hua， CHENG Meng-chun， WANG Li， XIAO Hong-bin
(Key Laboratory of Separation Science for Analytical Chemistry， Dalian Institute of Chemical Physics，Chinese Academy of Science， Dalian 116023， China)
[Abstract] Objective： To analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts. Method： The dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS. Different peaks were observed in total ion chromatograms and then identified according to their retention time， accurate mass weight， MS and MS/MS data. Result： After oral administration of Chuanxiong Rhizoma extracts， 3 compounds were absorbed into rat brain tissues through BBB. They were identified as senkyunolide I， senkyunolide A and ligustilide. Conclusion： The study is helpful for interpreting effective substance of Ligusticum chuanxiong.
[Key words] Ligusticum chuanxiong； brain tissue； chemical constituent； identification
doi：10.4268/cjcmm20122329
[责任编辑 陈玲], http://www.100md.com(左爱华 程孟春 王莉 肖红斌)
Analysis of chemical constituents of Chuanxiong Rhizoma absorbed into rat brain tissues by UPLC-Q-TOF-MS
ZUO Ai-hua， CHENG Meng-chun， WANG Li， XIAO Hong-bin
(Key Laboratory of Separation Science for Analytical Chemistry， Dalian Institute of Chemical Physics，Chinese Academy of Science， Dalian 116023， China)
[Abstract] Objective： To analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts. Method： The dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS. Different peaks were observed in total ion chromatograms and then identified according to their retention time， accurate mass weight， MS and MS/MS data. Result： After oral administration of Chuanxiong Rhizoma extracts， 3 compounds were absorbed into rat brain tissues through BBB. They were identified as senkyunolide I， senkyunolide A and ligustilide. Conclusion： The study is helpful for interpreting effective substance of Ligusticum chuanxiong.
[Key words] Ligusticum chuanxiong； brain tissue； chemical constituent； identification
doi：10.4268/cjcmm20122329
[责任编辑 陈玲], http://www.100md.com(左爱华 程孟春 王莉 肖红斌)